Phage-assisted continuous and non-continuous evolution
نویسندگان
چکیده
منابع مشابه
Experimental interrogation of the path dependence and stochasticity of protein evolution using phage-assisted continuous evolution.
To what extent are evolutionary outcomes determined by a population's recent environment, and to what extent do they depend on historical contingency and random chance? Here we apply a unique experimental system to investigate evolutionary reproducibility and path dependence at the protein level. We combined phage-assisted continuous evolution with high-throughput sequencing to analyze evolving...
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ژورنال
عنوان ژورنال: Nature Protocols
سال: 2020
ISSN: 1754-2189,1750-2799
DOI: 10.1038/s41596-020-00410-3